21 Mar 2021 ... Mitochondrial processes within cells sourced from hibernators and non- hibernators in altered gravity. Understanding the mechanisms and ...
9 Mar 2020 ... cells maintained functional mitochondria during hypothermia, without ... In contrast, non-hibernator cells accumulated ROS and showed ... use of an endogenous energy source in the hibernator originated HaK cells. ... to our hypothermia/rewarming protocol according to the experimental procedure. Then ...
Complexity Science. Mission Analysis. Propulsion. Mitochondrial processes within cells sourced from hibernators and non-hibernators in altered gravity.
9 Mar 2020 ... Mitochondrial failure is recognized to play an important role in a variety of ... and Survival in Hypothermia Compared to Non-Hibernator Cells ... In addition, hibernator cells survived hypothermia in the absence of extracellular energy sources, ... Reactive Oxygen Species / metabolism; Rewarming / methods ...
28 Apr 2015 ... In mammals, adaptations that allow for hibernation can be classified as those ... The primary source of fuel for mitochondrial respiration shifts from ... Most cellular processes that consume energy are directly or indirectly ...
14 Nov 2017 ... Disclosing the mechanisms that hibernators use to counteract cell death in hypothermic ... Mitochondria fulfil an important and well-known role in cell survival in I/R, either promoting survival by producing ATP to fuel cellular processes, ... like OPA1/DRP1, and manipulation of energy sources are of interest.
Abstract. Hibernation evolved in some small mammals that live in cold environments, ... This gradient is used to synthesize ATP, which can be used to power energetic reactions in the cell. ... requires an exogenous heat source, but hibernators in the wild will ... Most thermogenic heat is derived from mitochondrial processes.
13 Aug 2019 ... Similarly, low temperature incubation of kidney cells increased lipid peroxidation ... explaining the deleterious effects of hypothermia in transplantation procedures. ... Lowering temperature in perfused kidneys and isolated mitochondria ... to be the primary source of ROS, can have a relative less decrease in ...
Studies of hibernation in three ... reliant on palmitate oxidation as its source of ... BAT, which undergoes dramatic increases in mitochondrial activity and blood ...
28 Jan 2016 ... To date, our primary interest in hibernation has been geared towards ... utilizing their increased fat storage as the primary source of metabolic fuel (39, 40). ... and cell proliferation, mitochondrial metabolism, transmembrane ion ... Expectedly, protein synthesis was one of the first cellular processes show to ...
14 Aug 2017 ... Mammalian hibernators, such as golden-mantled ground squirrels ... primarily on the oxidation of these endogenous fat stores to fuel metabolic processes as internal ... In addition to serving as a primary energy source, fatty acids also influence ... Changes in the fatty acid composition of cellular membrane ...
1 Apr 2021 ... Hibernating mitochondria, the cool key to cellular protection and transplant ... Mitochondria, 'the powerhouses of the cell,' represent the main source of energy, ... ATP production, essential cell processes may fail, such as protein ... help to mimic hibernation in organs, creating new preservation techniques.
We are using the principles of hibernation for the development of compounds which ... chemical compounds that can enhance protective processes for human cells ... Mitochondria are the cell's source of energy and play an essential role in the ...
process and some of the (many) problems remaining unsolved in hibernation research. ... an eminent source of both general knowledge and detailed investigations in the field ( ... In general, if mammalian cells are transferred to an environment with a ... membrane-bound enzymatic processes in mitochondrial membranes.
9 Jun 2006 ... In these cells, UCP1 acts as a proton carrier activated by free fatty acids ... In the last three decades mitochondria were recognized not only as simple ... one ATP in the process of the so-called oxidative phosphorylation[17, 18]. ... in liver mitochondria from ground squirrels during hibernation and arousal.
Throughout the hibernation season, BAT mitochondrial uncoupling protein 1 ( UCP1) ... rate and use fat stored in white adipose tissue as their primary fuel source (2). ... were flash frozen in liquid nitrogen and stored at −80°C until processing. ... However, with more mitochondria per cell during hibernation, the oxidative ...
19 Feb 2018 ... Together, these processes constitute mitochondrial turnover. ... Intriguingly, hibernation induces mitophagy and loss of other organelles in the cone ... as well as the process of ageing itself, can hinder a cell's ability to maintain the ... Mitophagy induced by growth in non-fermentable carbon sources was ...
Body Protein Sparing in Hibernators: A Source for Biomedical Innovation. Article ... Only few studies explored mitochondria and cooling in these cell types, ... of the signaling molecules and processes known to influence hibernation and torpor, ...
Mitochondria are diminished in size and number, ribosomes are depleted, and the Golgi ... Calycal processes are thickened, and synaptic ... Key words: visual cells, cones, hibernation, renewal, retina. ... a source of fuel required for arousal.- 0).
22 Mar 2018 ... To examine whether mitochondria in human and GS iPSC- neurons respond differently to cold exposure, we monitored. 852 Cell 173, 851–863 ...
